Sergio Busquets, Frenkie de Jong, Philippe Coutinho and new arrival Miralem Pjanic battle it out for three spots in midfield with Francisco Trincao likely to wait his turn on the bench.
There is also a slight doubt over Martin Odegaard, who returned from loan from Real Sociedad over the summer and was in the starting 11 to face his former club a week ago.
Adrian scored his second and third in the 72nd minute and in stoppage time respectively, helping Chongqing to seal the victory.
"This work will continue until the opening of the Olympics," he said. "This crisis requires a lot of flexibilities and sacrifice from all of us.
Four minutes later it was 2-0 after Mane slotted the ball home after a terrible error from Chelsea keeper Kepa Arrizabalaga, whose attempted clearance was blocked by the forward.
The single-leg match was played behind closed doors in the city of Petah Tikva, after Beer Sheva's Turner Stadium was closed last month amid structural concerns.
Jiangsu sealed the win just three minutes later as Xie Pengfei converted a free kick and into the box and the ball hit at his teammate Li Ang, which created a rebound for Martins to score a volley.
"It will be strange to see you in another shirt and even stranger to come up against you on the pitch... I had already begun to imagine it but today I went into the dressing room and it truly dawned on me. It's going to be so difficult not to continue to share every day with you both on the pitch and away from it," the Argentinean wrote.
"Petr was important in that because goalkeeper is a very particular position. Petr Cech was the best in the world in that position for a long time, so he's obviously had a big say in this situation," explained Lampard of the former keeper, who in 2004 also joined Chelsea from Rennes.
Eibar has started the campaign with two defeats, while Athletic Bilbao lost in Granada on the opening day of the season. However, with fans unhappy at Athletic's disappointing end to last campaign, question marks over coach Gaizka Garitano's defensive instincts and a lack of goals in attack, a defeat in the Ipurua Stadium would only increase the discontent surrounding a club that has so far failed to make any summer signings. Enditem
"Jiangsu has more national team players with significant advantages in height, we should use some strategies to limit them," Wang added. Enditem