Things got worse for Ole Gunnar Solskjaer's team as Anthony Martial was sent off for lashing out at Erik Lamela, and Harry Kane and Son made it 4-1 before halftime.
Fiorentina loanee Pedro put the hosts ahead with a low strike before Bruno Henrique converted from the penalty spot after a Leo Gomes handball.
Leeds United and Manchester City produced a game that lived up to expectations in terms of entertainment with the teams taking one point each after a 1-1 draw.
In contrast, a solid nine goals adorned the match in Banska Bystrica.
"I'm living in a dream. I came here two weeks ago to my Roland-Garros qualifying but today I'm here in the quarterfinals," said the 26-year-old Italian qualifier, who hadn't played a Grand Slam main draw before this year's Australian Open, where she suffered an early first-round exit.
That performance has put Athletic coach Gaizka Garitano under pressure and both he and Machin need wins to assure they are still in their jobs after the international break.
Saturday also sees Valencia, who is second after a 1-0 win away to Real Sociedad, entertains Real Betis, who has lost consecutive matches after its winning start to the campaign. Betis coach Manuel Pellegrini needs an improvement after the poor first half display that saw his side thrashed 3-0 at Getafe on Wednesday.
Both the Women's World Cup (November 8-10) and Men's World Cup (November 13-15) will be held in Weihai, east China's Shandong province, while the Finals will return to Zhengzhou, Henan after 2019 from November 19 to 22.
"We haven't had an official game for quite a long time, thus leading to our huge anticipation towards it. All of us are excited about coming back on court," added China's national team center.
Moments later, new arrival Joel Pohjanpalo scored his first goal for Union only 35 seconds after coming on to put the result beyond doubt in the 64th minute.
XI'AN, China, Oct. 7 (Xinhua) -- The "2020 WE ARE ONE" ice art show was staged at the Xi'an Olympic Sports Center on Tuesday evening, with China's top figure skaters Pang Qing and Tong Jian delivering a stunning performance to celebrate the newly converted center.