Raul Jimenez put the away side in front with a half-volley from Castelo Podence's left-wing cross, before Romain Saiss's header from Neto's corner completed the scoring.
The Asian Games bronze medalist assigned her strength strategically all the way, in the last 600 meters, three runners took turns to lead, with Zhang winning the sprint finish. "I am from Yunnan province, training at high altitude has built up my endurance, and my strategy worked well today."
The first half of the fixture played in the north of Europe did not bring many scoring chances.
Valencia got a flying start to the season a week ago when they twice fought back from behind before winning 4-2 at home to Levante, and another fightback looked to be on the cards when Maxi Gomez scored an impressive goal in the first minute of the second half following a pass from Daniel Wass.
Valencia's 4-2 win at home to Levante was a major boost for Javi Gracia's side after a difficult summer and they will look to keep that positive feeling going even though Gracia continues to ask the board for new signings.
Earlier in the day, Zhaxi Yangben came first in the men's 50km race walk, with the winning mark of 3:52.19. Wang Rui finished second in 3:55.48, followed by Gong Fanglong in 3:59.01.
"The result didn't meet my expectation. I was just not in right tempo," Xie commented.
Feng Zhiqiang and Mo Jiadie came first in the men's and women's 400m hurdles. Xu Shuangshuang won women's 5,000m. In field events, Luo Na won women's hammer throw with 69.19m, while Wu Ruiting ranked first in the men's triple jump. Enditem
With this win, Al-Nassr replaced Al-Sadd SC at the top of Group D with seven points, while Sepahan remain in third place, two points off a knockout stage qualification spot ahead of matchday four's reverse fixture on Friday.
The South American zone World Cup qualifiers were originally scheduled to begin in late March but were suspended because of the COVID-19 pandemic.
The report said the decisions made through the NFABD Competition Standing Committee meeting took into consideration the weather conditions in the Sultanate.