But there was no place for striker Edinson Cavani, who has yet to find a new club after parting ways with Paris Saint-Germain in June. The 33-year-old has not played since March.
However, the top Shenzhen scorer was substituted with a suspected groin strain in the 43rd minute.
Leo Messi scored twice, and set up Philippe Coutinho, to show that he is fully committed on the pitch after a summer in which it looked as if he had a foot outside the door of the Camp Nou, while Barca produced a mobile performance in a side that contained Messi, Antoine Griezmann, Coutinho and newcomer Francisco Trincao.
The 10th seed, the oldest in the Rome Masters draw at 35, lost 6-0, 7-6 (2) to Musetti who is ranked 249th in the world.
The Foals responded but neither Stefan Lainer nor Lars Stindl was able to overcome Burki before the half-time whistle.
Stage One will be played across two blocks of eight days: September 13-20 and September 28-October 5. Enditem
In the other game played on Wednesday in the Suzhou division, Tianjin Teda held a 1-1 draw with Shijiazhuang Ever Bright. Frank Acheampong's header put Teda ahead in the 70th minute, but Chen Pu helped Shijiazhung level up in nine minutes.
The 46-year-old talked about the efforts to, in the future, find talented young Chinese players to join the club in the Rhine-Ruhr-region.
Calvert-Lewin's former side Sheffield United made a losing start to 2020-21, conceding two goals in the first six minutes as they went down 2-0 at home to Wolverhampton Wanderers.
Granada are still without veteran signing Jorge Molina, who tested positive for COVID-19 just after joining the club, but that didn't affect coach Diego Martinez's men as they opened the new La Liga season with a 2-0 home victory over Athletic Bilbao.
Li Ang netted a right-sided free-kick on 74 minutes to put the game beyond doubt, with a sweet finish for Suning.